Is CBD Treatment Useful for Fibromyalgia? Part 2 — s
What are cannabinoids?
Cannabinoids (e.g., THC and CBD) are the chemical compounds secreted by cannabis flowers that may have an effect on the physical body. They work by imitating compounds our bodies naturally give of, known as endocannabinoids, that have an effect on nerve, brain and immune cell activity.
Currently, there are 2 noted primary cannabinoid receptors: CB1 and CB2 receptors. CB1 receptors are found in the central nervous system, and in some peripheral tissues. They have an effect to craving, muscle management, pain, cognition, thermoregulation, and our stress response. CB2 receptors are mostly found in immune cells, and at a lower density within the central nervous system. CB2 activation is related to immune function and immune cell proliferation, inflammation, and pain. though these 2 cannabinoids receptors are studied comparatively extensively, there are a lot of cannabinoid receptors being examined.
Source: Szaflarski JP, Bebin EM, Cannabis, cannabidiol, and epilepsy–from receptors to clinical response. Epilepsy Behav. 2014;41: 277-82
How to Buy a CBD product?
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Make sure the merchandise you purchase has been third party research laboratory tested for the 3 P’s Potency (how much CBD is in it), Purity (any residual solvents from extraction process) and Pesticides. Third party research lab testing ought to be obtainable on the merchandise web site.
Unfortunately, CBD labels on products are usually inaccurate and unreliable as so much as their CBD content. A JAMA 2017 study found that almost seventieth of all product sold-out on-line made up of cannabidiol—an extract of the marijuana plant conjointly referred to as CBD—contained either higher or lower concentrations of the drug than indicated on the label. (The Real Risk of buying Medical Marijuana online by Amanda MacMillan November. 7, 2017 TIME Health)
CBD-rich product ought to be research lab tested to verify they’re freed from pesticides, and other contaminants. Best to avoid product extracted with cyanogenetic solvents like BHO, propane, alkane series or different hydrocarbons. choose product that utilize cleaner extraction strategies like critical greenhouse emission.
Beware of CBD vape pen oil that contains propylene glycol. once overheated, this chemical additive produces formaldehyde, a substance, as a byproduct, according to a 2015 report in the New England Journal of medicine.
Will CBD interact with my other medications?
At low doses of CBD, but 150mg total per day, it’s unlikely that vital drug-herb interactions will occur. but it’scontinuously potential that drug-herb interactions can occur, and this can be more likely the upper the dose. CBD and different plant cannabinoids can probably interact with several prescription drugs by inhibiting the activity of cytochrome P450, a family of liver enzymes. If you’re taking a drugs where maintaining a particular blood level is critical- like anti-seizure, anti-viral, blood-thinning medications- talk with your health care provider or pharmacistbefore attempting CBD.
Does CBD have an effect on appetite?
Unlike THC, CBD has negligible effects on appetite and satiation.
Does CBD cause side effects?
Typically CBD is not associated with many side effects but these have all been reported:
– Dry mouth
– Rarely can cause feelings of mild intoxication
What is the correct dosage of CBD?
A suitable dosage will vary from as little as a 5mg of CBD per day up to 150mg per day. ensure to start out low and go slow. Take a couple of little doses over the course of the day instead of one huge dose. Use an equivalentdose for several days. Observe the results and if necessary modify the amount. Don’t overdo it
Author Bio: Ginevra Liptan, MD, developed fibromyalgia while in medical school. She is a graduate of Tufts University School of Medicine and board-certified in internal medicine. Dr. Liptan is the founder and medical director of The Frida Center for Fibromyalgia and the author of The FibroManual: A Complete Fibromyalgia Treatment Guide For You…And Your Doctor and The Fibro Food Formula: A Real-Life Approach to Fibromyalgia Relief.
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