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Addison’s disease (main adrenal insufficiency) is an endocrine dysfunction of autoimmune foundation whereby the adrenal cortex, which produces the hormones cortisol and aldosterone, becomes step by step degenerated except symptoms are perceived; usually about 90% of the functional tissue is destroyed earlier than symptoms emerge. Newest therapy includes hormone replacement therapy, however the underlying peril has no solution. CBD has confirmed medical promise in attenuating the destruction of an enzyme, CYP450 21-hydroxylase, the degeneration of which is the acute pathology of Addison’s disease. This enzyme is an important step in the cascade that produces both aldosterone and cortisol. Moreover, it relieves loads of the symptoms by secondary mechanisms which would be general aspects in the CBD therapy of many other immune- and hormone-connected complications.
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